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Filtration

Liquid filtration steps are standard methods of modern biotechnology. Typical applications include:

  • Particle separation and microbial count reduction with membrane filter elements after media/buffer preparation
  • Purification of fermentation solutions or crude protein solutions by deep bed filtration (disk stack modules), cartridge filters, or membrane filters at the beginning of the downstream process
  • Purification of intermediate products by deep bed filtration
  • Microbial count reduction with membrane filter elements for intermediate and final products
  • Nanofiltration for virus removal

Vogelbusch Biopharma filtration skids are mobile and flexible solutions for all kinds of filtration applications. The typical features of Vogelbusch Biopharma filtration skids are:

  • Modular construction suitable for all kinds of liquid filtration operations
  • Flexible construction enables use with single or multiple filtration lines and different filter configurations
  • Filter lines with
    • Pre- and main filter units for microbial count reduction
    • Deep bed filtration modules and polishing filters
  • Simple adaptor mechanisms enable the use of all kinds of filter housings (single or multiple element housing with variable height)
  • The skid and all components are designed for CIP (cleaning in place) and SIP (sterilization/ sanitization in place)
  • Improved skid construction for
    • Flushing and product recovery steps (buffer and pure water inlet connections)
    • Separate SIP for filter groups (prefilter, main filter)
    • Filter integrity test of membrane filters
  • Monitoring of inlet and differential pressure
  • Monitoring and control of flow rates and volumes
  • Compatible with all standard process control systems
     

Applications:

The various liquid filtration methods are used in all areas of the modern biopharmaceutical industry. Thanks to the process-specific design of each individual unit, VOGELBUSCH filtration skids are used in various types of pharmaceutical plants. Some of the main applications are the production of antibodies, enzymes, and hormones.