Downstream

As an expert partner, Vogelbusch Biopharma designs and delivers process plants for product preparation or product purification. Depending on our customers' needs, we provide consultation services and we design and provide solutions for the complete downstream process, including buffer supply and accessories:
 

• Buffer preparation and supply: indispensable for all downstream processes
  • Batch tanks for buffers
  • Solid product infeed systems (e.g., Big Bag handling); including dust vacuuming to prevent contamination
  • Buffer filtration (e.g., bioburden reduction with 0.2 µm filters)
  • Filling stations for buffer reserve tanks or bags

• Chromatography systems: an important purification step in many processes
  • Inline dilution, gradient systems for chromatography
  • Fractionation in mobile tanks or bags
  • Chromatography columns
  • Package units and equipment for chromatography columns

• Ultra- and diafiltration: Concentration and buffer changing between different purification steps
  • Skids for all kinds of membrane systems (flat screen, hollow fiber, etc.), UF

• Reaction tanks: with special accessories for all kinds of operations
  • PEGlation
  • Reduction reactions
  • Crystallization
  • Mobile tanks and small-volume containers for chemicals

• Filtration: for particle separation or bioburden reduction
• Ultracentrifugation
• Product filling and refrigeration
  • Sterile filtration
  • Filling solutions, laminar flow workbenches
  • Freezing systems